Protein detail

CD2AP

CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

Entry name CD2AP	UniProt ID Q9Y5K6	EVMP confidence score 0.75
Supporting publications (n) 30	Transmembrane count	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function (5)

Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Ensembl

ENSG00000198087

Entrez Gene Symbol

CD2AP

Gene Synonym

CMS

Gene Description

CD2 associated protein

Chromosome

Position

47477789-47627263

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization3

Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway7

Protein Function (5)

Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (19)

Page 1 of 2

Molecular Function (8)

Biological Process (3)

KEGG (2)

Reactome (2)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence17

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CD2AP	Q9Y5K6	ACTB	P60709	Yes	Yes	No	SIGNOR	SIGNOR:29175910
FA83G	A6ND36	CD2AP	Q9Y5K6	Yes	Yes	No	SIGNOR	SIGNOR:29175910

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Cbl-Cd2ap complex	CBL CD2AP	P22681 Q9Y5K6	1:1	Compleat	Compleat:HC850	15001553
	CD2AP NPHS1 NPHS2 PTCD1 SH3KBP1 YWHAZ	O60500 O75127 P63104 Q96B97 Q9NP85 Q9Y5K6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6787
	CBLB CD2AP	Q13191 Q9Y5K6	1:1	PDB	PDB:2j6f
	CD2AP MVB12B TSG101 VPS28 VPS37A VPS37B	Q8NEZ2 Q99816 Q9H7P6 Q9H9H4 Q9UK41 Q9Y5K6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5006
	CD2AP RIN3	Q8TB24 Q9Y5K6	3:3	PDB	PDB:4wciPDB:3u23
	CD2AP NUDC	Q9Y266 Q9Y5K6	0:0	hu.MAP
	CD2AP	Q9Y5K6	12	PDB	PDB:2j6k

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	4	38113368 40189497 32560723 38207106

Sequence, Structure & Domains12

Sequences

Length

639

Mass

71,451

Sequence

MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS

3D Structural Models

Helix

159..161; 489..492; 503..505

Beta Strand

4..6; 25..30; 37..42; 45..50; 53..56; 112..115; 134..142; 145..150; 153..158; 162..164

3D Structure

NMR spectroscopy (1); X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias

168..177; Basic and acidic residues; 195..207; Polar residues; 341..351; Pro residues; 356..379; Basic and acidic residues; 385..395; Pro residues

Motif

336..352; SH3-binding; 378..397; SH3-binding; 410..422; SH3-binding

Coiled Coil

577..638

Domain (CC)

The Pro-rich domain may mediate binding to SH3 domains.; DOMAIN: Potential homodimerization is mediated by the coiled coil domain.

Domain (FT)

1..59; SH3 1; truncated; 108..167; SH3 2; 269..330; SH3 3

Region

1..175; Interaction with ANLN and localization to the midbody; 168..209; Disordered; 227..256; Disordered; 333..428; Disordered

Clinical Relevance4

Antibody (3)

HPA003267 HPA003326 CAB004352

Interaction Protein (10)

ENSG00000077549ENSG00000095585ENSG00000100599ENSG00000110395ENSG00000114423ENSG00000116824ENSG00000147010ENSG00000170248ENSG00000177885ENSG00000198898

Interaction Count

Interaction Dataset (3)

biogrid_opencellintact_biogridbiogrid_bioplex

Supporting Publications30

PMID	Title	Abstract
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
37563857	Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications.	No abstract available
37926756	Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.	No abstract available
38014595	Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available

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