Protein detail

VATD

V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)

Entry name VATD	UniProt ID Q9Y5K8	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Essential proteinsMetabolic proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)

Protein Class (3)

Essential proteinsMetabolic proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000100554

Entrez Gene Symbol

ATP6V1D

Gene Synonym (3)

ATP6MVATDVMA8

Gene Description

ATPase H+ transporting V1 subunit D

Chromosome

Position

67294371-67360265

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Tissue Specificbrain

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (15)

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Molecular Function (2)

Biological Process (3)

KEGG (11)

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Reactome (16)

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Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence20

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Protein Complex Composition (13)

13 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Vacuolar proton translocating ATPase complexATP6V0A1 variant	ATP6AP1 ATP6AP2 ATP6V0A1 ATP6V0B ATP6V0C ATP6V1A ATP6V1D ATP6V1F ATP6V1H RNASEK	O75787 P27449 P38606 Q15904 Q16864 Q6P5S7 Q93050 Q99437 Q9UI12 Q9Y5K8	1:9:3:1:1:1:1:1:1:1	ComplexPortal	PDB:6WLWintact:EBI-9017296	33065002 14755292 32001091
Vacuolar proton translocating ATPase complexATP6V0A3 variant	ATP6AP1 ATP6AP2 ATP6V0B ATP6V0C ATP6V1A ATP6V1D ATP6V1F ATP6V1H RNASEK TCIRG1	O75787 P27449 P38606 Q13488 Q15904 Q16864 Q6P5S7 Q99437 Q9UI12 Q9Y5K8	1:9:3:1:1:1:1:1:1:1	ComplexPortal	PDB:6WLWintact:EBI-27064562	33065002 14755292 32001091
Vacuolar proton translocating ATPase complexATP6V0A4 variant	ATP6AP1 ATP6AP2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V1A ATP6V1D ATP6V1F ATP6V1H RNASEK	O75787 P27449 P38606 Q15904 Q16864 Q6P5S7 Q99437 Q9HBG4 Q9UI12 Q9Y5K8	1:9:3:1:1:1:1:1:1:1	ComplexPortal	PDB:6WLWintact:EBI-27065093	33065002 14755292 32001091
vacuolar proton-transporting V-type ATPase complex	ATP6V0A4 ATP6V0D1 ATP6V0D2 ATP6V1B1 ATP6V1D ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3	O75348 O95670 P15313 P61421 Q16864 Q8N8Y2 Q96LB4 Q9HBG4 Q9Y5K8	1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2536	12414817 18752060 10973252 11118322
	ATP6V1A ATP6V1B2 ATP6V1D ATP6V1G1 ATP6V1H SCARB2	O75348 P21281 P38606 Q14108 Q9UI12 Q9Y5K8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7899
	ATP6V1D PFKP SERPINE2 SND1 TLN1	P07093 Q01813 Q7KZF4 Q9Y490 Q9Y5K8	0:0:0:0:0	hu.MAP
	ATP6V1A ATP6V1B2 ATP6V1D ATP6V1H EPHX1 SCARB2	P07099 P21281 P38606 Q14108 Q9UI12 Q9Y5K8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4141
	ATP6V1A ATP6V1B2 ATP6V1D AZU1 DDOST SCARB2	P20160 P21281 P38606 P39656 Q14108 Q9Y5K8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5066
	ATP6V0A1 ATP6V0D1 ATP6V1A ATP6V1B2 ATP6V1D KIAA2013 SCARB2	P21281 P38606 P61421 Q14108 Q8IYS2 Q93050 Q9Y5K8	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7822
	ATP6V0D1 ATP6V1A ATP6V1B2 ATP6V1D	P21281 P38606 P61421 Q9Y5K8	0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30915084

Sequence, Structure & Domains8

Sequences

Length

247

Mass

28,263

Sequence

MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE

3D Structural Models

Helix

15..73; 80..85; 129..174; 176..215

Beta Strand

94..101; 104..110; 118..126

3D Structure

Electron microscopy (8)

Domain & Motif Annotations

Protein Families

V-ATPase D subunit family

Sequence Similarities

Belongs to the V-ATPase D subunit family.

Clinical Relevance4

Antibody (2)

HPA031515 HPA057316

Interaction Protein (14)

ENSG00000033627ENSG00000047249ENSG00000110719ENSG00000114573ENSG00000116039ENSG00000128524ENSG00000131100ENSG00000136888ENSG00000147416ENSG00000155097ENSG00000159720ENSG00000171159ENSG00000182220ENSG00000250565

Interaction Count

Interaction Dataset (5)

biogrid_opencellbiogrid_bioplexbiogrid_opencell_bioplexintact_biogrid_opencell_bioplexintact_biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available