Protein detail

LRRF2

Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Entry name
LRRF2
UniProt ID
Q9Y608
EVMP confidence score
0.60
Supporting publications (n)
18
Transmembrane count
Protein classification
Predicted intracellular proteinsTranscription factors
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
  • Transcription factors:Yet undefined DNA-binding domains
  • Predicted intracellular proteins
Ensembl
ENSG00000093167
Entrez Gene Symbol
LRRFIP2
Gene Synonym
HUFI-2
Gene Description
LRR binding FLII interacting protein 2
Chromosome
3
Position
37052626-37183689
Supporting publications (n)
18
EVMP confidence score
0.60
Fluorescence & Localization1
Cell SpecificColonocytes
Function & Pathway5
Protein Function (2)
  • Transcription factors:Yet undefined DNA-binding domains
  • Predicted intracellular proteins
Cellular Component
GO:0005575 cellular_component
Molecular Function (2)
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence10

Ligand-Receptor Signaling (2)

2 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
LRRF2Q9Y608DVL3Q92997YesYesNoSIGNORSignaLink3SignaLink3:20006983SignaLink3:23331499SIGNOR:15677333

Protein Complex Composition (6)

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry137329381
Sequence, Structure & Domains10

Sequences

Length
721
Mass
82,171
Sequence
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSRLSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9Y608-1; Sequence=Displayed; Name=2; IsoId=Q9Y608-2; Sequence=VSP_019675, VSP_019676, VSP_019677; Name=3; IsoId=Q9Y608-3; Sequence=VSP_019674; Name=4; IsoId=Q9Y608-4; Sequence=VSP_019675, VSP_019677; Name=5; IsoId=Q9Y608-5; Sequence=VSP_056969, VSP_056970, VSP_056971, VSP_056972, VSP_019676, VSP_056973
Alternative Sequence
1..621; Missing (in isoform 3); 60..291; Missing (in isoform 2 and isoform 4); 60..76; Missing (in isoform 5); 111..124; Missing (in isoform 5); 146..202; Missing (in isoform 5); 220..291; Missing (in isoform 5); 346..369; Missing (in isoform 2 and isoform 5); 457..521; Missing (in isoform 2 and isoform 4); 489..522; Missing (in isoform 5)

Domain & Motif Annotations

Compositional Bias
237..251; Polar residues; 305..338; Polar residues
Coiled Coil
22..49; 349..524; 566..714
Region
1..370; DVL3-binding; 232..262; Disordered; 295..338; Disordered
Protein Families
LRRFIP family
Sequence Similarities
Belongs to the LRRFIP family.
Clinical Relevance4
Antibody (2)
HPA035956HPA042023
Interaction Protein
ENSG00000177731
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications17
PMIDTitleAbstract
24769233Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.Most interestingly, the involvement of extracellular vesicles in transferring toxic proteins such as α-synuclein and β-amyloid has been postulated as one of the mechanisms involved in the spreading of neurodegeneration to different brain areas.
27894104Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.No abstract available
28986585Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.No abstract available
29148239Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.No abstract available
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No abstract available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No abstract available
34817906Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.No abstract available
35194965Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles.No abstract available
35611462Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.No abstract available
36398564Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.No abstract available
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