Protein detail

LRRF2

Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Entry name LRRF2	UniProt ID Q9Y608	EVMP confidence score 0.47
Supporting publications (n) 17	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

Basic Information

Protein Names

Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Protein Class (2)

Predicted intracellular proteinsTranscription factors

Protein Function (2)

Transcription factors:Yet undefined DNA-binding domains
Predicted intracellular proteins

Ensembl

ENSG00000093167

Entrez Gene Symbol

LRRFIP2

Gene Synonym

HUFI-2

Gene Description

LRR binding FLII interacting protein 2

Chromosome

Position

37052626-37183689

Supporting publications (n)

EVMP confidence score

0.47

Fluorescence & Localization

Cell SpecificColonocytes

Function & Pathway

Protein Function (2)

Transcription factors:Yet undefined DNA-binding domains
Predicted intracellular proteins

Cellular Component

GO:0005575 cellular_component

Molecular Function (2)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence10

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI
intracellular	intracellular	OmniPath

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LRRF2	Q9Y608	DVL3	Q92997	Yes	Yes		SIGNORSignaLink3	SignaLink3:20006983 SignaLink3:23331499 SIGNOR:15677333

Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster175	FLII LRRFIP1 LRRFIP2	Q13045 Q32MZ4 Q9Y608	1:1:1	Compleat	Compleat:HC195	22036573
	IQGAP3 LRRFIP2 MYH14 MYL12B MYL6 MYO18A	O14950 O95411 P60660 Q7Z406 Q86VI3 Q9Y608	0:0:0:0:0:0	hu.MAP2
	IQGAP3 LRRFIP2 MYH14 MYL12B MYL6 MYO18A	O14950 P60660 Q7Z406 Q86VI3 Q92614 Q9Y608	0:0:0:0:0:0	hu.MAP2
	ACTB CARM1 FLII LRRFIP2 PRKCSH	P14314 P60709 Q13045 Q86X55 Q9Y608	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3890
	LRRFIP2 TMOD3 UBXN2A	P68543 Q9NYL9 Q9Y608	0:0:0	hu.MAP
	LRRFIP2 TMOD3	Q9NYL9 Q9Y608	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	1	37329381

Sequence, Structure & Domains

Sequences

Length

721

Mass

82,171

Sequence

MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSRLSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9Y608-1; Sequence=Displayed; Name=2; IsoId=Q9Y608-2; Sequence=VSP_019675, VSP_019676, VSP_019677; Name=3; IsoId=Q9Y608-3; Sequence=VSP_019674; Name=4; IsoId=Q9Y608-4; Sequence=VSP_019675, VSP_019677; Name=5; IsoId=Q9Y608-5; Sequence=VSP_056969, VSP_056970, VSP_056971, VSP_056972, VSP_019676, VSP_056973

Alternative Sequence

1..621; Missing (in isoform 3); 60..291; Missing (in isoform 2 and isoform 4); 60..76; Missing (in isoform 5); 111..124; Missing (in isoform 5); 146..202; Missing (in isoform 5); 220..291; Missing (in isoform 5); 346..369; Missing (in isoform 2 and isoform 5); 457..521; Missing (in isoform 2 and isoform 4); 489..522; Missing (in isoform 5)

Domain & Motif Annotations

Compositional Bias

237..251; Polar residues; 305..338; Polar residues

Coiled Coil

22..49; 349..524; 566..714

Region

1..370; DVL3-binding; 232..262; Disordered; 295..338; Disordered

Protein Families

LRRFIP family

Sequence Similarities

Belongs to the LRRFIP family.

Clinical Relevance

Antibody (2)

HPA035956 HPA042023

Interaction Protein

ENSG00000177731

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications17

PMID	Title	Related sentences
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39409015	SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy.	No related sentences available
39569406	Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.	No related sentences available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No related sentences available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No related sentences available
41197617	Age-(in)dependent altered molecular mechanisms in Parkinson's disease through extracellular vesicle proteome and lipidome.	No related sentences available

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