Protein detail

LRRF2

Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Entry name LRRF2	UniProt ID Q9Y608	EVMP confidence score 0.60
Supporting publications (n) 18	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Protein Class (2)

Predicted intracellular proteinsTranscription factors

Protein Function (2)

Transcription factors:Yet undefined DNA-binding domains
Predicted intracellular proteins

Ensembl

ENSG00000093167

Entrez Gene Symbol

LRRFIP2

Gene Synonym

HUFI-2

Gene Description

LRR binding FLII interacting protein 2

Chromosome

Position

37052626-37183689

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization1

Cell SpecificColonocytes

Function & Pathway5

Protein Function (2)

Transcription factors:Yet undefined DNA-binding domains
Predicted intracellular proteins

Cellular Component

GO:0005575 cellular_component

Molecular Function (2)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence10

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LRRF2	Q9Y608	DVL3	Q92997	Yes	Yes	No	SIGNORSignaLink3	SignaLink3:20006983 SignaLink3:23331499 SIGNOR:15677333

Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster175	FLII LRRFIP1 LRRFIP2	Q13045 Q32MZ4 Q9Y608	1:1:1	Compleat	Compleat:HC195	22036573
	IQGAP3 LRRFIP2 MYH14 MYL12B MYL6 MYO18A	O14950 O95411 P60660 Q7Z406 Q86VI3 Q9Y608	0:0:0:0:0:0	hu.MAP2
	IQGAP3 LRRFIP2 MYH14 MYL12B MYL6 MYO18A	O14950 P60660 Q7Z406 Q86VI3 Q92614 Q9Y608	0:0:0:0:0:0	hu.MAP2
	ACTB CARM1 FLII LRRFIP2 PRKCSH	P14314 P60709 Q13045 Q86X55 Q9Y608	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3890
	LRRFIP2 TMOD3 UBXN2A	P68543 Q9NYL9 Q9Y608	0:0:0	hu.MAP
	LRRFIP2 TMOD3	Q9NYL9 Q9Y608	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	1	37329381

Sequence, Structure & Domains10

Sequences

Length

721

Mass

82,171

Sequence

MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSRLSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9Y608-1; Sequence=Displayed; Name=2; IsoId=Q9Y608-2; Sequence=VSP_019675, VSP_019676, VSP_019677; Name=3; IsoId=Q9Y608-3; Sequence=VSP_019674; Name=4; IsoId=Q9Y608-4; Sequence=VSP_019675, VSP_019677; Name=5; IsoId=Q9Y608-5; Sequence=VSP_056969, VSP_056970, VSP_056971, VSP_056972, VSP_019676, VSP_056973

Alternative Sequence

1..621; Missing (in isoform 3); 60..291; Missing (in isoform 2 and isoform 4); 60..76; Missing (in isoform 5); 111..124; Missing (in isoform 5); 146..202; Missing (in isoform 5); 220..291; Missing (in isoform 5); 346..369; Missing (in isoform 2 and isoform 5); 457..521; Missing (in isoform 2 and isoform 4); 489..522; Missing (in isoform 5)

Domain & Motif Annotations

Compositional Bias

237..251; Polar residues; 305..338; Polar residues

Coiled Coil

22..49; 349..524; 566..714

Region

1..370; DVL3-binding; 232..262; Disordered; 295..338; Disordered

Protein Families

LRRFIP family

Sequence Similarities

Belongs to the LRRFIP family.

Clinical Relevance4

Antibody (2)

HPA035956 HPA042023

Interaction Protein

ENSG00000177731

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications17

PMID	Title	Abstract
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39409015	SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy.	No abstract available
39569406	Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.	No abstract available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No abstract available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available
41197617	Age-(in)dependent altered molecular mechanisms in Parkinson's disease through extracellular vesicle proteome and lipidome.	No abstract available

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