Protein detail
SO1B1
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Entry name SO1B1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Protein Class (7)
Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Transmembrane
29..48; Helical; Name=1; 68..88; Helical; Name=2; 95..119; Helical; Name=3; 169..197; Helical; Name=4; 217..237; Helical; Name=5; 256..280; Helical; Name=6; 332..353; Helical; Name=7; 374..397; Helical; Name=8; 402..425; Helical; Name=9; 538..560; Helical; Name=10; 570..595; Helical; Name=11; 630..647; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
LST-1OATP-COATP1B1SLC21A6
Gene Description
Solute carrier organic anion transporter family member 1B1
Chromosome
12
Position
21131194-21239796
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway7
Protein Function (4)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Cellular Component (4)
Molecular Function (5)
- GO:0008514 organic anion transmembrane transporter activity
- GO:0015125 bile acid transmembrane transporter activity
- GO:0015132 prostaglandin transmembrane transporter activity
- GO:0015347 sodium-independent organic anion transmembrane transporter activity
- GO:0015349 thyroid hormone transmembrane transporter activity
Biological Process (3)
Reactome (14)
- R-hsa-9754706 atorvastatin adme
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-9748784 drug adme
- R-hsa-189483 heme degradation
- R-hsa-556833 metabolism of lipids
- R-hsa-189445 metabolism of porphyrins
- R-hsa-8957322 metabolism of steroids
- R-hsa-879518 organic anion transport by slco transporters
- R-hsa-159418 recycling of bile acids and salts
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Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence37
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLCO1B1 | LYN | P07948 | Y | 645 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (30)
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slco | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LYN | P07948 | SO1B1 | Q9Y6L6 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:33664059 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BLZF1FAM83BSETD9SLC30A5SLC30A6SLCO1B1USO1 | O60763Q5T0W9Q6NXT4Q8NE22Q8TAD4Q9H2G9Q9Y6L6 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| BLZF1SETD9SLC30A5SLC30A6SLCO1B1USO1 | O60763Q6NXT4Q8NE22Q8TAD4Q9H2G9Q9Y6L6 | 0:0:0:0:0:0 | hu.MAP2 | |||
| BLZF1SLCO1B1USO1 | O60763Q9H2G9Q9Y6L6 | 0:0:0 | hu.MAP2 | |||
| SLCO1B1USO1 | O60763Q9Y6L6 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains11
Sequences
Length
691
Mass
76,449
Sequence
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
3D Structural Models
Turn
161..164; 185..187; 373..375; 436..438; 484..488; 510..512; 560..562; 583..585
Helix
27..50; 52..59; 63..70; 72..87; 88..90; 93..110; 113..117; 166..169; 171..184; 188..198; 204..215; 218..230; 260..271; 275..277; 324..333; 336..366; 376..400; 404..422; 423..427; 458..460; 528..549; 554..559; 565..567; 568..582; 587..595; 596..598; 618..650
Beta Strand
232..237; 251..253; 451..453; 473..475; 480..482; 495..498; 501..503; 505..507; 513..515; 518..522; 599..602; 613..616
3D Structure
Electron microscopy (9)
Domain & Motif Annotations
Domain (CC)
A conserved histidine residue in the third TMD (His-115) may play an essential role in the pH sensitivity of SLCO1B1/OATP1B1-mediated substrate transport.
Domain (FT)
453..508; Kazal-like
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance2
Drugs (70)
ETOPOSIDEGLYCYRRHIZIC ACIDISOSILYBIN BSILIBININROSUVASTATINIDARUBICINFENOFIBRATE MICRONIZEDLORAZEPAMESTROPIPATESILYBIN BELAGOLIXDULAGLUTIDEPRAVASTATIN SODIUMGEMFIBROZILTENIVASTATINDILTIAZEM HYDROCHLORIDECARVEDILOL[3H]ESTRADIOL-17&BETA-GLUCURONIDEEZETIMIBE / SIMVASTATINPACLITAXELVILOXAZINEFLUOXETINE HYDROCHLORIDECASPOFUNGINESTRONEETHAMBUTOL HYDROCHLORIDEMISOPROSTOLRIFAMYCIN SVELTROMBOPAGLOVASTATIN ACIDGLUCARPIDASEMETHOTREXATESULFOBROMOPHTHALEINSILIDIANINCLOFIBRATEATORVASTATIN CALCIUM TRIHYDRATETROGLITAZONEEPIRUBICINWARFARINOLMESARTAN MEDOXOMILFLUDARABINEGOSERELIN ACETATEINDOCYANINE GREEN ACID FORMEZETIMIBEESTRONE SULFATELEVOTHYROXINEERYTHROMYCINFUROSEMIDEGEMCITABINECERIVASTATINAMPRENAVIRDOCETAXEL ANHYDROUSDAUNORUBICIN LIPOSOMALCYCLOSPORINESORAFENIBANHYDROUS DEXTROSEDOXORUBICIN HYDROCHLORIDEATRASENTANMK-8245GEMTUZUMAB OZOGAMICINVALSARTANPYRAZINAMIDERIFAMPINCYTARABINEISOSILYBIN AROCURONIUMSN-38LANSOPRAZOLECYCLOPHOSPHAMIDE ANHYDROUSMITOXANTRONE
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40222457 | Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement. | No abstract available |