Protein detail
SO1B1
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Entry name SO1B1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Transmembrane
29..48; Helical; Name=1; 68..88; Helical; Name=2; 95..119; Helical; Name=3; 169..197; Helical; Name=4; 217..237; Helical; Name=5; 256..280; Helical; Name=6; 332..353; Helical; Name=7; 374..397; Helical; Name=8; 402..425; Helical; Name=9; 538..560; Helical; Name=10; 570..595; Helical; Name=11; 630..647; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
LST-1OATP-COATP1B1SLC21A6
Gene Description
Solute carrier organic anion transporter family member 1B1
Chromosome
12
Position
21131194-21239796
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Cellular Component
Molecular Function
- GO:0008514 organic anion transmembrane transporter activity
- GO:0015125 bile acid transmembrane transporter activity
- GO:0015132 prostaglandin transmembrane transporter activity
- GO:0015347 sodium-independent organic anion transmembrane transporter activity
- GO:0015349 thyroid hormone transmembrane transporter activity
Biological Process
Reactome
- R-hsa-9754706 atorvastatin adme
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-9748784 drug adme
- R-hsa-189483 heme degradation
- R-hsa-556833 metabolism of lipids
- R-hsa-189445 metabolism of porphyrins
- R-hsa-8957322 metabolism of steroids
- R-hsa-879518 organic anion transport by slco transporters
- R-hsa-159418 recycling of bile acids and salts
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLCO1B1 | LYN | P07948 | Y | 645 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LYN | P07948 | SO1B1 | Q9Y6L6 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:33664059 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BLZF1FAM83BSETD9SLC30A5SLC30A6SLCO1B1USO1 | O60763Q5T0W9Q6NXT4Q8NE22Q8TAD4Q9H2G9Q9Y6L6 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| BLZF1SETD9SLC30A5SLC30A6SLCO1B1USO1 | O60763Q6NXT4Q8NE22Q8TAD4Q9H2G9Q9Y6L6 | 0:0:0:0:0:0 | hu.MAP2 | |||
| BLZF1SLCO1B1USO1 | O60763Q9H2G9Q9Y6L6 | 0:0:0 | hu.MAP2 | |||
| SLCO1B1USO1 | O60763Q9Y6L6 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
691
Mass
76,449
Sequence
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
3D Structural Models
Turn
161..164; 185..187; 373..375; 436..438; 484..488; 510..512; 560..562; 583..585
Helix
27..50; 52..59; 63..70; 72..87; 88..90; 93..110; 113..117; 166..169; 171..184; 188..198; 204..215; 218..230; 260..271; 275..277; 324..333; 336..366; 376..400; 404..422; 423..427; 458..460; 528..549; 554..559; 565..567; 568..582; 587..595; 596..598; 618..650
Beta Strand
232..237; 251..253; 451..453; 473..475; 480..482; 495..498; 501..503; 505..507; 513..515; 518..522; 599..602; 613..616
3D Structure
Electron microscopy (9)
Domain & Motif Annotations
Domain (CC)
A conserved histidine residue in the third TMD (His-115) may play an essential role in the pH sensitivity of SLCO1B1/OATP1B1-mediated substrate transport.
Domain (FT)
453..508; Kazal-like
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance
Drugs
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