Protein detail

TNR11

Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)

Entry name TNR11	UniProt ID Q9Y6Q6	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)

Protein Class

CD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
CD markers
Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Disease related genes

Transmembrane

213..233; Helical

Transmembrane Count

Ensembl

ENSG00000141655

Entrez Gene Symbol

TNFRSF11A

Gene Synonym

CD265FEOLOH18CR1ODFRPDB2RANKTRANCE-R

Gene Description

TNF receptor superfamily member 11a

Chromosome

Position

62325287-62391288

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAlveolar cells type 2Single-Nuclei Brain Specificependymal cellSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
CD markers
Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

64 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	CellCall	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No
tumor_necrosis_factor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TNF11	O14788	TNR11	Q9Y6Q6	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020LRdb	Baccin2019:9367155 ICELLNET:11239407 LRdb:11581298 NetPath:20483727 NetPath:9520411 SIGNOR:12897775 connectomeDB2020:9367155LRdb:94HPMR:15110169 Cellinker:11581298 NetPath:14741739 IntAct:23333834 HPRD:9367155 Cellinker:9367155 connectomeDB2020:11581298 Baccin2019:11581298 HPMR:11581298 CellTalkDB:11581298
TRAF6	Q9Y4K3	TNR11	Q9Y6Q6	Yes	Yes	No	NetPathMPPISIGNORELMHINTHPRDBioGRIDInnateDBSPIKE_LC	BioGRID:11809792 InnateDB:9685412 SPIKE_LC:17145710 HINT:10025951 HINT:10075662 HPRD:10075662 HINT:9852070 InnateDB:11809792 InnateDB:10025951 ELM:12140561 HPRD:10635328 SIGNOR:10075662 HINT:11406619 HINT:9685412 NetPath:11809792 MPPI:9685412 NetPath:10635328 HINT:12140561 HPRD:10025951 NetPath:17544369 NetPath:10075662 NetPath:11406619 SPIKE_LC:10075662 InnateDB:11406619 HINT:11809792 HPRD:9685412

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TNFRSF11A TRAF6	Q9Y4K3 Q9Y6Q6	1:1	PDB	PDB:1lb5

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	2	40189497 32560723

Sequence, Structure & Domains

Sequences

Length

616

Mass

66,034

Sequence

MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMCYPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSENYLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9Y6Q6-1; Sequence=Displayed; Name=2; Synonyms=delta7,8,9; IsoId=Q9Y6Q6-2; Sequence=VSP_046901; Name=3; Synonyms=delta8,9; IsoId=Q9Y6Q6-3; Sequence=VSP_054180; Name=4; Synonyms=delta9; IsoId=Q9Y6Q6-4; Sequence=VSP_054181, VSP_054182; Name=5; Synonyms=exon9a; IsoId=Q9Y6Q6-5; Sequence=VSP_054183; Name=RANK-e5a; IsoId=Q9Y6Q6-6; Sequence=VSP_054179

Alternative Sequence

143..157; LQLNKDTVCKPCLAG -> C (in isoform RANK-e5a); 206..522; Missing (in isoform 2); 244..522; Missing (in isoform 3); 263; S -> M (in isoform 4); 264..616; Missing (in isoform 4); 523..616; GNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA -> D (in isoform 5)

3D Structural Models

Beta Strand

345..348

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

483..493; Basic and acidic residues; 499..508; Low complexity; 524..536; Polar residues; 570..580; Basic and acidic residues

Repeat

34..68; TNFR-Cys 1; 71..112; TNFR-Cys 2; 114..151; TNFR-Cys 3; 154..194; TNFR-Cys 4

Region

468..536; Disordered; 544..549; Required for interaction with EEIG1 and osteoclast differentiation; 556..616; Disordered

Clinical Relevance

Disease Involvement

DeafnessDisease variantOsteopetrosis

Drugs

PAMIDRONATE DICLOFENAC SODIUM ASPIRIN DENOSUMAB ACETAMINOPHEN ZOLEDRONIC ACID ANHYDROUS NULL RISPERIDONE

Antibody

CAB010391 HPA047976

Interaction Protein

ENSG00000127191

Interaction Count

Interaction Dataset

intact_biogrid