Protein detail

TNR11

Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)

Entry name TNR11	UniProt ID Q9Y6Q6	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)

Protein Class

CD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
CD markers
Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Disease related genes

Transmembrane

213..233; Helical

Transmembrane Count

Ensembl

ENSG00000141655

Entrez Gene Symbol

TNFRSF11A

Gene Synonym

CD265FEOLOH18CR1ODFRPDB2RANKTRANCE-R

Gene Description

TNF receptor superfamily member 11a

Chromosome

Position

62325287-62391288

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAlveolar cells type 2Single-Nuclei Brain Specificependymal cellSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
CD markers
Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

64 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

Page 7 of 7Previous

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TNF11	O14788	TNR11	Q9Y6Q6	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020LRdb	Baccin2019:9367155 ICELLNET:11239407 LRdb:11581298 NetPath:20483727 NetPath:9520411 SIGNOR:12897775 connectomeDB2020:9367155LRdb:94HPMR:15110169 Cellinker:11581298 NetPath:14741739 IntAct:23333834 HPRD:9367155 Cellinker:9367155 connectomeDB2020:11581298 Baccin2019:11581298 HPMR:11581298 CellTalkDB:11581298
TRAF6	Q9Y4K3	TNR11	Q9Y6Q6	Yes	Yes	No	NetPathMPPISIGNORELMHINTHPRDBioGRIDInnateDBSPIKE_LC	BioGRID:11809792 InnateDB:9685412 SPIKE_LC:17145710 HINT:10025951 HINT:10075662 HPRD:10075662 HINT:9852070 InnateDB:11809792 InnateDB:10025951 ELM:12140561 HPRD:10635328 SIGNOR:10075662 HINT:11406619 HINT:9685412 NetPath:11809792 MPPI:9685412 NetPath:10635328 HINT:12140561 HPRD:10025951 NetPath:17544369 NetPath:10075662 NetPath:11406619 SPIKE_LC:10075662 InnateDB:11406619 HINT:11809792 HPRD:9685412

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TNFRSF11A TRAF6	Q9Y4K3 Q9Y6Q6	1:1	PDB	PDB:1lb5

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	2	40189497 32560723

Sequence, Structure & Domains

Sequences

Length

616

Mass

66,034

Sequence

MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMCYPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSENYLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9Y6Q6-1; Sequence=Displayed; Name=2; Synonyms=delta7,8,9; IsoId=Q9Y6Q6-2; Sequence=VSP_046901; Name=3; Synonyms=delta8,9; IsoId=Q9Y6Q6-3; Sequence=VSP_054180; Name=4; Synonyms=delta9; IsoId=Q9Y6Q6-4; Sequence=VSP_054181, VSP_054182; Name=5; Synonyms=exon9a; IsoId=Q9Y6Q6-5; Sequence=VSP_054183; Name=RANK-e5a; IsoId=Q9Y6Q6-6; Sequence=VSP_054179

Alternative Sequence

143..157; LQLNKDTVCKPCLAG -> C (in isoform RANK-e5a); 206..522; Missing (in isoform 2); 244..522; Missing (in isoform 3); 263; S -> M (in isoform 4); 264..616; Missing (in isoform 4); 523..616; GNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA -> D (in isoform 5)

3D Structural Models

Beta Strand

345..348

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

483..493; Basic and acidic residues; 499..508; Low complexity; 524..536; Polar residues; 570..580; Basic and acidic residues

Repeat

34..68; TNFR-Cys 1; 71..112; TNFR-Cys 2; 114..151; TNFR-Cys 3; 154..194; TNFR-Cys 4

Region

468..536; Disordered; 544..549; Required for interaction with EEIG1 and osteoclast differentiation; 556..616; Disordered

Clinical Relevance

Disease Involvement

DeafnessDisease variantOsteopetrosis

Drugs

PAMIDRONATE DICLOFENAC SODIUM ASPIRIN DENOSUMAB ACETAMINOPHEN ZOLEDRONIC ACID ANHYDROUS NULL RISPERIDONE

Antibody

CAB010391 HPA047976

Interaction Protein

ENSG00000127191

Interaction Count

Interaction Dataset

intact_biogrid