Protein detail

S10A6

Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)

Entry name
S10A6
UniProt ID
P06703
EVMP confidence score
0.72
Supporting publications (n)
12
Transmembrane count
Protein classification
Cancer-related genesPlasma proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)
Protein Class (3)
Cancer-related genesPlasma proteinsPredicted intracellular proteins
Protein Function (2)
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted intracellular proteins
Ensembl
ENSG00000197956
Entrez Gene Symbol
S100A6
Gene Synonym (4)
2A9CABPCACYPRA
Gene Description
S100 calcium binding protein A6
Chromosome
1
Position
153534599-153536244
Supporting publications (n)
12
EVMP confidence score
0.72
Fluorescence & Localization2
Tissue SpecificintestineCell SpecificColonocytes
Function & Pathway6
Protein Function (2)
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted intracellular proteins
Cellular Component (11)
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Molecular Function (8)
Biological Process (3)
KEGG
hsa04382 Cornified envelope formation
Mediation Categories
Other mediation
Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ligandligandMatrisomeYesNoYesNoNo
ligandligandOmniPathYesNoYesNoNo
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CACY homodimer complexS100A6P067032CORUMPDBPDB:1k9kCORUM:19829578461

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing137953466
Sequence, Structure & Domains10

Sequences

Length
90
Mass
10,180
Sequence
MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYNEALKG

3D Structural Models

Turn
63..65
Helix
4..20; 31..41; 45..47; 51..62; 70..84; 86..88
Beta Strand
22..24; 28..30; 67..69
3D Structure
NMR spectroscopy (1); X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)
12..47; EF-hand 1; 48..83; EF-hand 2
Protein Families
S-100 family
Sequence Similarities
Belongs to the S-100 family.
Clinical Relevance5
Disease Involvement
Cancer-related genes
Antibody (4)
CAB002601HPA007575CAB040549CAB047354
Interaction Protein (4)
ENSG00000004478ENSG00000116161ENSG00000135679ENSG00000160307
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications12
PMIDTitleAbstract
39573935Time-Lapse Acquisition of Both Freely Secreted Proteome and Exosome Encapsulated Proteome in Live Organoids' Microenvironment.No abstract available
40748658Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.No abstract available
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