Protein detail

FGR

Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)

Entry name FGR	UniProt ID P09769	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)

Protein Class (5)

Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Ensembl

ENSG00000000938

Entrez Gene Symbol

FGR

Gene Synonym (3)

c-fgrp55c-fgrSRC2

Gene Description

FGR proto-oncogene, Src family tyrosine kinase

Chromosome

Position

27612064-27635185

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificnaive CD8 T-cell

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Cellular Component (11)

Page 1 of 2

Molecular Function (9)

Biological Process (3)

KEGG

hsa04062 Chemokine signaling pathway

Reactome (12)

Page 1 of 2

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence56

Enzyme-Mediated Modification (21)

21 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FGR	MATK	P42679	Y	412	phosphorylation	PhosphoNetworks
FGR	TYRO3	Q06418	Y	34	phosphorylation	PhosphoNetworks
FGR	TYRO3	Q06418	Y	523	phosphorylation	PhosphoNetworks
FGR	PTK2B	Q14289	Y	180	phosphorylation	PhosphoNetworks
FGR	PTK2B	Q14289	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper
FGR	GNAI2	P04899	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:11160627
FGR	PTPN13	Q12923	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:11983165
FGR	CD244	Q9BZW8	Y	412	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:22238634
FGR	CD226	Q15762	Y	412	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:22238634
FGR	FYN	P06241	Y	412	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (22)

22 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGR	P09769	ELMO1	Q92556	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:15952790
FGR	P09769	HCLS1	P14317	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	SIGNOR:10066823 KEA:9104825 HPRD-phos:10066823 phosphoELM:10066823 KEA:8578591 KEA:9183008 ProtMapper:10066823 HPRD:10066823 phosphoELM:9183008 dbPTM:10066823 KEA:96108162 dbPTM:8611520 KEA:10066823
FGR	P09769	KCND3	Q9UK17	Yes	Yes	No	SIGNOR	SIGNOR:22198508
FGR	P09769	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714
FGR	P09769	KSYK	P43405	Yes	Yes	No	DOMINOWangPhosphoPointSIGNORHPRDBioGRIDSPIKE_LCLit-BM-17	Lit-BM-17:15536084 DOMINO:15536084 BioGRID:11672534 SIGNOR:21746961 SPIKE_LC:15536084 HPRD:11672534 Lit-BM-17:11672534
CSK	P41240	FGR	P09769	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEALi2012PhosphoNetworksNCI-PID_ProtMapperHPRDKinexus_KEAWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	HPRD:7515063 HINT:8612628 KEA:8612628 ProtMapper:11489946 HPRD:8612628 ProtMapper:14967142 ProtMapper:16537894 HINT:7515063 ProtMapper:7515063 ProtMapper:8612628 SIGNOR:7515063 HPRD-phos:7515063 iPTMnet:8612628 HPRD-phos:8612628 KEA:7515063 phosphoELM:7515063
FGR	P09769	TBK1	Q9UHD2	Yes	No	Yes	PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:28618271
FGR	P09769	SRC	P12931	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEALi2012SIGNOR_ProtMapper	KEA:12387813 HPRD:12468645 ProtMapper:12387813 ProtMapper:9208935 KEA:9208935 KEA:3103926 HPRD:7678701 KEA:7678701 ProtMapper:7678701 iPTMnet:9208935 KEA:12468645 HPRD:9208935 SIGNOR:9208935 ProtMapper:12468645 HPRD:12387813
SRC	P12931	FGR	P09769	Yes	No	No	HPRDdbPTMSIGNOR	HPRD:12468645 HPRD:7678701 dbPTM:19369195 SIGNOR:9208935 HPRD:9208935 HPRD:12387813
FGR	P09769	NEMO	Q9Y6K9	Yes	No	Yes	SIGNORProtMapperInnateDBREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:23131831 SIGNOR:23131831 InnateDB:20098747

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CDK14 FGR	O94921 P09769	0:0	hu.MAPhu.MAP2
	FGR	P09769	2	PDB	PDB:7uy0

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	1	38113368

Sequence, Structure & Domains10

Sequences

Length

529

Mass

59,479

Sequence

MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT

3D Structural Models

Turn

120..122; 189..191; 283..285; 514..516

Helix

130..132; 139..141; 151..158; 219..228; 260..262; 300..310; 342..345; 349..352; 356..375; 385..387; 392..394; 403..406; 422..424; 427..432; 437..452; 464..472; 485..494; 499..501; 505..513

Beta Strand

82..86; 92..95; 103..108; 112..119; 125..129; 133..135; 167..172; 174..176; 180..188; 192..202; 204..206; 208..211; 216..218; 231..235; 249..252; 263..271; 273..282; 286..293; 321..325; 327..329; 331..334; 388..390; 396..398; 407..412; 522..524

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

77..138; SH3; 144..241; SH2; 263..516; Protein kinase

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
SRC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Clinical Relevance6

Disease Involvement

Proto-oncogene

Antibody

HPA002024

Interaction Protein

ENSG00000146648

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications6

PMID	Title	Abstract
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38354507	Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available