Protein detail
IDE
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Entry name IDE | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 0 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Protein Class (5)
EnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function (6)
- Predicted intracellular proteins
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Description
Insulin degrading enzyme
Chromosome
10
Position
92451684-92574096
Supporting publications (n)
0
EVMP confidence score
0.47
Fluorescence & Localization
Cell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lipBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function (6)
- Predicted intracellular proteins
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- FDA approved drug targets:Small molecule drugs
Cellular Component (11)
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005777 peroxisome
- GO:0005782 peroxisomal matrix
- GO:0005829 cytosol
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016323 basolateral plasma membrane
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Molecular Function (10)
- GO:0001618 virus receptor activity
- GO:0004175 endopeptidase activity
- GO:0004222 metalloendopeptidase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008270 zinc ion binding
- GO:0042277 peptide binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0043559 insulin binding
Biological Process (3)
Reactome (8)
- R-hsa-5688426 deubiquitination
- R-hsa-77387 insulin receptor recycling
- R-hsa-9033241 peroxisomal protein import
- R-hsa-597592 post translational protein modification
- R-hsa-9609507 protein localization
- R-hsa-74752 signaling by insulin receptor
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-5689880 ub specific processing proteases
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence50
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | Yes | ||||
| insulin_degrading | cell_surface_peptidase | OmniPath | Yes | Yes | |||
| m16_metallopeptidase | cell_surface_peptidase | OmniPath | Yes | Yes | |||
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | Yes | |||
| cell_surface_peptidase | cell_surface_peptidase | OmniPath | Yes | Yes | |||
| secreted_peptidase | secreted_peptidase | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| secreted | secreted | UniProt_keyword | Yes | ||||
| secreted | secreted | UniProt_location | Yes |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IDE | P14735 | INS | P01308 | Yes | Yes | SIGNORHPRDHINTIntActDIP | HINT:19321446HINT:29273204HPRD:11145591HPRD:17051221HINT:17051221IntAct:17051221HINT:29596046SIGNOR:29596046DIP:17051221 |
Protein Complex Composition (26)
26 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IDEINS | P01308P14735 | 2:2 | PDB | PDB:7rziPDB:7rzePDB:2g54PDB:5cjoPDB:2wc0PDB:7rzfPDB:6b3qPDB:2g56PDB:5wobPDB:2wbyPDB:6bfc | ||
| IDEIGF2 | P01344P14735 | 2:2 | PDB | PDB:3e4z | ||
| APPIDE | P05067P14735 | 2:2 | PDB | PDB:2g47PDB:4m1cPDB:2wk3 | ||
| IDEUBC | P0CG48P14735 | 2:2 | PDB | PDB:3ofi | ||
| IDEP0DOX5P0DOX7 | P0DOX5P0DOX7P14735 | 2:2:2 | PDB | PDB:6bf7PDB:6bf9 | ||
| IDEP0DOX5Q6GMX0 | P0DOX5P14735Q6GMX0 | 2:2:2 | PDB | PDB:6b7z | ||
| CCL3IDE | P10147P14735 | 2:2 | PDB | PDB:3h44 | ||
| IAPPIDE | P10997P14735 | 2:2 | PDB | PDB:3hgzPDB:2g48 | ||
| ATRCHAF1AHMGB2IDEIFIH1MLH1MSH2MSH3MSH6PCNAPRKDCRPA1RPA2RPA4XPA | P12004P14735P15927P20585P23025P26583P27694P40692P43246P52701P78527Q13111Q13156Q13535Q9BYX4 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9546 | ||
| CCL4IDE | P13236P14735 | 2:2 | PDB | PDB:4ral |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 32331267 |
Sequence, Structure & Domains
Sequences
Length
1,019
Mass
117,968
Sequence
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14735-1; Sequence=Displayed; Name=2; IsoId=P14735-2; Sequence=VSP_044303
Alternative Sequence
1..555; Missing (in isoform 2)
3D Structural Models
Turn
133..135; 326..328; 441..443; 449..454; 486..488; 494..496; 824..827
Helix
96..98; 106..113; 114..116; 126..132; 155..157; 158..166; 167..169; 176..194; 197..207; 214..216; 223..226; 228..232; 237..248; 251..253; 264..275; 295..297; 323..325; 330..338; 346..352; 381..385; 387..404; 408..423; 430..440; 446..448; 461..468; 473..475; 483..485; 507..514; 581..583; 587..613; 638..650; 656..672; 673..675; 678..690; 697..704; 709..721; 735..753; 760..762; 802..823; 856..876; 879..894; 900..912; 920..928; 933..943; 995..1000
Beta Strand
47..50; 63..69; 74..79; 84..93; 101..104; 118..121; 123..125; 137..142; 147..154; 254..262; 276..278; 298..304; 307..309; 312..319; 359..367; 370..378; 477..481; 499..504; 549..553; 555..563; 565..567; 570..579; 584..586; 616..623; 626..635; 691..693; 722..732; 775..782; 787..799; 831..840; 843..854; 945..947; 949..951; 952..959; 990..992
3D Structure
Electron microscopy (14); X-ray crystallography (47)
Domain & Motif Annotations
Motif
853..858; SlyX motif
Domain (CC)
The SlyX motif may be involved in the non-conventional secretion of the protein.
Protein Families
Peptidase M16 family
Sequence Similarities
Belongs to the peptidase M16 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases (2)
Biomarker
Phase 2; Approved
Drug Targets
FDA approved drug targets
Antibody
Interaction Protein
ENSG00000089163
Interaction Count
1
Interaction Dataset
intact_biogrid