Protein detail

CAD13

Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)

Entry name CAD13	UniProt ID P55290	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000140945

Entrez Gene Symbol

CDH13

Gene Synonym

CDHH

Gene Description

Cadherin 13

Chromosome

Position

82626965-83800640

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (14)

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Molecular Function (8)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Reactome (3)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence35

Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
adhesion	adhesion	OmniPath	Yes	Yes	No	No	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	Yes
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	Yes
transmembrane	transmembrane	OmniPath	No	No	No	No	Yes
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	Yes
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	Yes
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	CSPA	No	No	No	No	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	OmniPath	No	No	No	No	Yes
cell_surface	cell_surface	Surfaceome	No	No	No	No	Yes

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CAD13	P55290	CTNB1	P35222	Yes	Yes	No	SIGNOR	SIGNOR:21255999

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	37322475 41307968 31805958 34576246 37204515

Sequence, Structure & Domains10

Sequences

Length

713

Mass

78,287

Sequence

MQPRTPLVLCVLLSQVLLLTSAEDLDCTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVLLLSLFSLACL

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P55290-1; Sequence=Displayed; Name=2; IsoId=P55290-2; Sequence=VSP_042696, VSP_042697; Name=3; IsoId=P55290-3; Sequence=VSP_042794, VSP_042795; Name=4; IsoId=P55290-4; Sequence=VSP_046714; Name=5; IsoId=P55290-5; Sequence=VSP_053739

Alternative Sequence

1..14; MQPRTPLVLCVLLS -> MKTPPGASSRTKCSRELRSFCAFSCPRAKQPTCTAWFPQQEHPSENGPQMPGRDPPAASTM (in isoform 4); 123..161; Missing (in isoform 5); 162..190; VVDSDRPERSKFRLTGKGVDQEPKGIFRI -> RTHNPINSELLLNEGITADLNPCITILAI (in isoform 2); 162..175; VVDSDRPERSKFRL -> MKIWQVLCLARWLT (in isoform 3); 176..713; Missing (in isoform 3); 191..713; Missing (in isoform 2)

3D Structural Models

Turn

179..181; 192..194; 205..207

Beta Strand

145..148; 157..161; 163..167; 172..178; 182..184; 187..190; 196..199; 209..218; 224..236; 238..241

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Domain (CC)

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Domain (FT)

139..245; Cadherin 1; 246..363; Cadherin 2; 364..477; Cadherin 3; 478..585; Cadherin 4; 584..694; Cadherin 5

Clinical Relevance2

Drugs (13)

KETANSERIN [125I]IODOVINYL-TBZ ASPIRIN RESERPINE DEUTETRABENAZINE PERPHENAZINE DEXTROAMPHETAMINE SULFATE [3H]TBZOH CLOPIDOGREL [125I]7-AZIDO-8-IODOKETANSERINE TETRABENAZINE SORAFENIB [11C]DTBZ

Antibody (2)

HPA001380 CAB025863

Supporting Publications1

PMID	Title	Abstract
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.