Protein detail

MICA

MHC class I polypeptide-related sequence A (MIC-A)

Entry name MICA	UniProt ID Q29983	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

MHC class I polypeptide-related sequence A (MIC-A)

Protein Function

Predicted intracellular proteins

Transmembrane

308..328; Helical

Transmembrane Count

Ensembl

ENSG00000204520

Entrez Gene Symbol

MICA

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (2)

Canonical Pathways (2)

M82 Pid ret pathway
M142 Pid ajdiss 2pathway

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence54

Ligand-Receptor Signaling (42)

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No

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Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MICALL1 MICALL2 NARS2 RAB8B SYTL4	Q8IY33 Q8N3F8 Q92930 Q96C24 Q96I59	0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains12

Sequences

Length

383

Mass

42,915

Sequence

MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MICA1; IsoId=Q29983-1; Sequence=Displayed; Name=2; Synonyms=MICA2; IsoId=Q29983-2; Sequence=VSP_055366

Alternative Sequence

109..204; Missing (in isoform 2)

3D Structural Models

Turn

87..90; 145..148; 198..200

Helix

79..81; 83..86; 91..101; 156..171; 177..197; 217..219; 248..250; 277..279

Beta Strand

26..37; 46..51; 54..60; 63..65; 71..75; 109..121; 127..135; 138..144; 149..151; 208..214; 220..233; 236..241; 251..253; 260..262; 264..273; 280..286; 289..294

3D Structure

X-ray crystallography (10)

Domain & Motif Annotations

Domain (FT)

207..296; Ig-like C1-type

Protein Families (2)

MHC class I family
MIC subfamily

Sequence Similarities

Belongs to the MHC class I family. MIC subfamily.

Clinical Relevance1

Drugs (3)

RECOMBINANT 70-KD HEAT-SHOCK PROTEIN CARBAMAZEPINE NULL

Supporting Publications1

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available