Protein detail
NTRI
Neurotrimin (hNT) (IgLON family member 2)
Entry name NTRI | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neurotrimin (hNT) (IgLON family member 2)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CEPU-1HNTIGLON2NTRI
Gene Description
Neurotrimin
Chromosome
11
Position
131370478-132336822
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | No | Yes |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | No | Yes |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | Yes |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | Yes |
| peripheral | peripheral | UniProt_location | No | No | No | No | Yes |
| peripheral | peripheral | OmniPath | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | No | Yes |
Regulatory Interaction Network
0 records.
Protein Complex Composition
11 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CENPBNTMT2 | P07199Q5VVY1 | 2:2 | PDB | PDB:6kdr | ||
| DRG1ETF1LRRC41NTMT1POLA1ZC3H15 | P09884P62495Q15345Q8WU90Q9BV86Q9Y295 | 0:0:0:0:0:0 | hu.MAP2 | |||
| NTMT2RCC1 | P18754Q5VVY1 | 2:2 | PDB | PDB:6dub | ||
| NTMT1RCC1 | P18754Q9BV86 | 2:2 | PDB | PDB:5e2bPDB:5e1oPDB:5e2aPDB:5e1dPDB:5e1bPDB:5e1m | ||
| CENPANTMT2 | P49450Q5VVY1 | 1:1 | PDB | PDB:6kds | ||
| CENPANTMT1 | P49450Q9BV86 | 2:2 | PDB | PDB:5cvdPDB:6kdq | ||
| NTMT1TIRAP | P58753Q9BV86 | 0:0 | hu.MAP | |||
| DRG1GNL3LLRRC41NTMT1 | Q15345Q9BV86Q9NVN8Q9Y295 | 0:0:0:0 | hu.MAP | |||
| DRG1LRRC41NTMT1 | Q15345Q9BV86Q9Y295 | 0:0:0 | hu.MAP | |||
| NTMT1 | Q9BV86 | 2 | PDB | PDB:2ex4PDB:6wh8PDB:7k3dPDB:7u1mPDB:7ss1 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains
Sequences
Length
344
Mass
37,971
Sequence
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9P121-1; Sequence=Displayed; Name=2; IsoId=Q9P121-2; Sequence=VSP_010939; Name=3; IsoId=Q9P121-3; Sequence=VSP_010940, VSP_010941; Name=4; IsoId=Q9P121-4; Sequence=VSP_041165
Alternative Sequence
1..27; MGVCGYLFLPWKCLVVVSLRLLFLVPT -> MKTIQPKMHNSISWAIFTGLAALCLFQ (in isoform 2); 311; F -> FEVKTTALTPWK (in isoform 4); 313..316; PGAV -> ETVL (in isoform 3); 317..344; Missing (in isoform 3)
3D Structural Models
Helix
107..109; 193..195
Beta Strand
45..48; 53..55; 66..70; 73..77; 88..92; 99..102; 111..117; 125..141; 145..148; 153..155; 157..163; 166..171; 184..190; 197..204; 206..208; 211..225; 241..249; 252..256; 271..273; 275..280; 292..298; 303..309
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
39..126; Ig-like C2-type 1; 136..218; Ig-like C2-type 2; 222..309; Ig-like C2-type 3
Protein Families
- Immunoglobulin superfamily
- IgLON family
Sequence Similarities
Belongs to the immunoglobulin superfamily. IgLON family.
Clinical Relevance
Antibody